A variety of therapeutic approaches have been described as benefiting patients with chronic fatigue syndrome (CFS). Since no cause for CFS has been identified and the pathophysiology remains unknown, treatment programs are directed at relief of symptoms, with the goal of the patient regaining some level of pre-existing function and well-being. Although desirable, a rapid return to pre-illness health may not be realistic, and patients who expect this prompt recovery and do not experience it may exacerbate their symptoms because of overexertion, become frustrated, and may become more refractory to rehabilitation.

Decisions regarding treatment for CFS or any chronically fatiguing illness should be made only in consultation with a health care provider. The health care provider, together with the patient, will develop an individually tailored program that provides the greatest benefit. This treatment program will be based on assessment of the patient. s overall medical condition and current symptoms, and will be modified over time on the basis of regular follow-up and assessment of the patient. s changing condition. Currently, most health care providers with experience in treating persons with CFS use some combination of the therapies discussed below. Persons who have questions about a particular treatment should contact a qualified health care provider, local medical society, or university medical school for additional information.